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Class I indication for angiotensin receptor blocker therapy for reducing the risk of HF hospitalization and reducing the risk of premature death:

- CHF + NYHA Class II - IV + LVEF < 40% + poor tolerance of ACEI.

Class I indication for angiotensin receptor blocker therapy for reducing the risk of HF hospitalization:
- CHF + NYHA Class II - IV symptoms persisting despite treatment with ACEI and B-blocker + LVEF < 40% + poor tolerance of MRA.

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