Class IIa indications for ivabradine therapy for reducing the risk of HF hospitalization:
CHF + NYHA Class II - IV symptoms persisting despite treatment with ACEI and MRA and B-blocker + sinus rhythm + heart rate > 70 b.p.m. + LVEF < 35%,
CHF + NYHA Class II - IV symptoms persisting despite treatment with ACEI and ARB and B-blocker +sinus rhythm + heart rate > 70 b.p.m. + LVEF < 35%,
CHF + NYHA Class II - IV symptoms persisting despite treatment with ARB and MRA and B-blocker + sinus rhythm + heart rate > 70 b.p.m. + LVEF < 35%.

Class IIb indication for ivabradine therapy for reducing the risk of HF hospitalization:
CHF + NYHA Class II - IV symptoms + sinus rhythm + heart rate > 70 b.p.m. + LVEF < 35% + poor tolerance of B-blockers.